Having completed my PhD in molecular cell biology at Uppsala University in 2007, I joined AstraZeneca as a postdoctoral researcher in 2009, which offered a great opportunity to introduce in situ proximity ligation assay (isPLA) on projects within the analgesia and Alzheimer’s disease areas. I successfully established isPLA technology into the company, to strengthen the target validation and show activation of target molecules in human tissue and translatable animal models.
In 2011, I joined the IMED RIA unit as a Senior Research Scientist, applying state-of-the-art molecular and visualisation technologies to address questions 关于 the activation of the target/protein of interest. I was then promoted to an Associate Principal Scientist role, where I have been involved in activities including target identification, target validation and patient segmentation approaches. I have been acting as translational science lead, ensuring that translational aspects were considered during project progression, using innovative and creative approaches to overcome obstacles and follow the science.
An international assignment in 2015 gave me the opportunity to spend a year at the IMED Asia and Emerging Markets IMED unit at the Innovation Centre China (ICC) in Shanghai, working in a cross-cultural 团队 at this leading-edge translational science centre. The role included acting as a link between the ICC and IMED RIA unit in Gothenburg.
Since coming back from Shanghai in July 2016, I have been leading my 团队 to understand the role of innate lymphoid cells in type 2 asthma in an effort to discover ways to regulate their activity in the disease.
AstraZeneca’s reputation and novel medications have had a major impact on the lives of many people – not least when my young son was suffering from asthma.
Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment.皇冠官网app下载
Cuppen BV, Pardali K, Kraan MC, Marijnissen AC, Yrlid L, Olsson M, Bijlsma JW, Lafeber FP, Fritsch-Stork RD.
Rheumatol Int. 2017 Apr;37(4):531-536. doi: 10.1007/s00296-017-3653-1. Epub 2017 Jan 28.
Profiling cellular protein complexes by proximity ligation with dual tag microarray readout.皇冠官网app下载
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase.皇冠官网app下载
Zieba A, Pardali K, Söderberg O, Lindbom L, Nyström E, Moustakas A, Heldin CH, Landegren U.
Mol Cell Proteomics. 2012 Jul;11(7):M111.013482. doi: 10.1074/mcp.M111.013482. Epub 2012 Mar 22.
Bright-field microscopy visualization of proteins and protein complexes by in situ proximity ligation with peroxidase detection.皇冠官网app下载
Zieba A, Wählby C, Hjelm F, Jordan L, Berg J, Landegren U, Pardali K.
Clin Chem. 2010 Jan;56(1):99-110. doi: 10.1373/clinchem.2009.134452. Epub 2009 Nov 19.
A detailed analysis of 3D subcellular signal localization.皇冠官网app下载
Pinidiyaarachchi A, Zieba A, Allalou A, Pardali K, Wählby C.
Cytometry A. 2009 Apr;75(4):319-28. doi: 10.1002/cyto.a.20663.
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.皇冠官网app下载
Valcourt U, Thuault S, Pardali K, Heldin CH, Moustakas A.
Mol Oncol. 2007 Jun;1(1):55-71. doi: 10.1016/j.molonc.2007.02.002. Epub 2007 Mar 14.
Notch signaling is necessary for epithelial growth arrest by TGF-beta.皇冠官网app下载
Niimi H, Pardali K, Vanlandewijck M, Heldin CH, Moustakas A.
J Cell Biol. 2007 Feb 26;176(5):695-707.
Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.皇冠官网app下载
Pardali K, Moustakas A.
Biochim Biophys Acta. 2007 Jan;1775(1):21-62. Epub 2006 Jul 8. Review.
Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1).皇冠官网app下载
Pardali K, Kowanetz M, Heldin CH, Moustakas A.
J Cell Physiol. 2005 Jul;204(1):260-72.
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.皇冠官网app下载
Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, Ten Dijke P, Heldin CH, Ericsson J, Moustakas A.
Mol Cell Biol. 2003 Jul;23(13):4494-510.
Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation.皇冠官网app下载
Moustakas A, Pardali K, Gaal A, Heldin CH.
Immunol Lett. 2002 Jun 3;82(1-2):85-91. Review.
SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4.皇冠官网app下载
Kardassis D, Pardali K, Zannis VI.
J Biol Chem. 2000 Dec 29;275(52):41405-14.
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.皇冠官网app下载
Pardali K, Kurisaki A, Morén A, ten Dijke P, Kardassis D, Moustakas A.
J Biol Chem. 2000 Sep 22;275(38):29244-56.
c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.皇冠官网app下载
Kardassis D, Papakosta P, Pardali K, Moustakas A.
J Biol Chem. 1999 Oct 8;274(41):29572-81.
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.皇冠官网app下载
D Cook, D Brown, R Alexander, R E March, P Morgan, G Satterthwaite & M N Pangalos.
Nature Reviews Drug Discovery. 2014 June; 13:419-431.
I wanted to be part of a team that has the ability to help and make a difference in people’s lives. The patient is at the centre of everything we do.
Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals.